Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

539 questions · 553 findings · 58 reviews · Airways

No studies found 37 · 6.7%GRADE not reported 8 · 1.4%Very low 27 · 4.9%Low 161 · 29.1%Moderate 219 · 39.6%High 101 · 18.3%

Bromhexine vs placebo

Frequency and duration of exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Adverse events · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Symptoms sputum colour Scale used not reported · people with bronchiectasis

RhDNase showed no clear difference in symptoms sputum colour Scale used not reported compared with placebo (low certainty).

1 finding from 1 review

RhDNase vs placebo

Deaths · people with bronchiectasis

RhDNase showed no clear difference in deaths compared with placebo (low certainty).

1 finding from 1 review

RhDNase vs placebo

Lung function: FEV1 mL (percentage change from baseline) · people with bronchiectasis

RhDNase showed no clear difference in lung function % change FEV1 compared with placebo (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Hospital admissions · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Bromhexine vs placebo

Adverse events · people with bronchiectasis

Bromhexine showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Bromhexine vs placebo

Symptoms difficulty in expectoration · people with bronchiectasis

Bromhexine showed no clear difference in symptoms difficulty in expectoration compared with placebo (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Deaths · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review