Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

551 questions · 579 findings · 72 reviews · Headline outcomes only

No studies found 158 · 27.3%GRADE not reported 44 · 7.6%Very low 173 · 29.9%Low 112 · 19.3%Moderate 66 · 11.4%High 26 · 4.5%

Intervention not reported

Pain (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

2b. Adequate immune response (seroprotection) against tetanus (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention showed no clear difference in 2b. Adequate immune response (seroprotection) against tetanus… (moderate certainty).

1 finding from 1 review

Intervention not reported

4b. Persistent inconsolable crying4 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

It is very uncertain whether the intervention changes 4b. Persistent inconsolable crying4 (very low certainty).

1 finding from 1 review

Intervention not reported

Severe local reaction8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower severe local reaction8 (moderate certainty).

1 finding from 1 review

Intervention not reported

Non‐severe local reaction11 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower non‐severe local reaction11 (moderate certainty).

1 finding from 1 review

Intervention not reported

Fever15 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

It is very uncertain whether the intervention changes fever15 (very low certainty).

1 finding from 1 review

Intervention not reported

2c. Adequate immune response (seroprotection) against pertussis (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

2d. Adequate immune response (seroprotection) against Haemophilus influenzae type b disease (surrogate outcome) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to higher 2d. Adequate immune response (seroprotection) against Haemophilus… (moderate certainty).

1 finding from 1 review

Intervention not reported

Pain (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4a. Procedural crying (during and immediately after the vaccination procedure) (not measured) · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

4b. Persistent inconsolable crying4 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

It is very uncertain whether the intervention changes 4b. Persistent inconsolable crying4 (very low certainty).

1 finding from 1 review

Intervention not reported

Severe local reaction8 · infants aged approximately 2 to 6 months undergoing vaccination in the anterolateral thigh with a DTwP‐Hib vaccine

The intervention probably leads to lower severe local reaction8 (moderate certainty).

1 finding from 1 review