What do systematic reviews say?

Acupuncture vs metoclopramide

It is very uncertain whether acupuncture changes reduction or cessation in vomiting compared with metoclopramide (very low certainty).

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  RR 1.51 [0.92, 2.48]
  1 study · 81 participants
  Very low

Acupuncture vs metoclopramide

The review found no eligible studies for this question.

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Pyridoxine vs placebo

• Interventions for treating hyperemesis gravidarum 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Low

Beta stimulant vs placebo

Beta stimulant may leads to higher cephalic presentation at birth (primary) compared with placebo (low certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 1.68 [1.14, 2.48]
  5 studies · 459 participants
  Low

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

It is very uncertain whether regional analgesia (with tocolysis) changes caesarean section (primary) compared with no intervention of regional analgesia (with or without tocolysis) (very low certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 0.74 [0.4, 1.37]
  3 studies · 279 participants
  Very low

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

Regional analgesia (with tocolysis) showed no clear difference in fetal bradycardia (primary) compared with no intervention of regional analgesia (with or without tocolysis) (low certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 1.48 [0.62, 3.57]
  2 studies · 210 participants
  Low

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

Regional analgesia (with tocolysis) probably leads to lower failed external cephalic version compared with no intervention of regional analgesia (with or without tocolysis) (moderate certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 0.61 [0.43, 0.86]
  5 studies · 409 participants
  Moderate

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Beta stimulant vs placebo

Beta stimulant probably leads to lower cephalic vaginal birth not achieved (CS + breech vaginal birth)… compared with placebo (moderate certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 0.75 [0.6, 0.92]
  4 studies · 399 participants
  Moderate

Beta stimulant vs placebo

Beta stimulant probably leads to lower caesarean section (primary) compared with placebo (moderate certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 0.77 [0.67, 0.88]
  6 studies · 742 participants
  Moderate

Beta stimulant vs placebo

It is very uncertain whether beta stimulant changes fetal bradycardia (primary) compared with placebo (very low certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 2.81 [0.12, 66.17]
  1 study · 58 participants
  Very low

Beta stimulant vs placebo

Beta stimulant probably leads to lower failed external cephalic version compared with placebo (moderate certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 0.7 [0.6, 0.82]
  9 studies · 900 participants
  Moderate

Beta stimulant vs placebo

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Beta stimulant vs placebo

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

It is very uncertain whether regional analgesia (with tocolysis) changes cephalic presentation at birth (primary) compared with no intervention of regional analgesia (with or without tocolysis) (very low certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 1.63 [0.75, 3.53]
  3 studies · 279 participants
  Very low

Regional analgesia (with tocolysis) vs no intervention of regional analgesia (with or without tocolysis)

Regional analgesia (with tocolysis) may leads to lower cephalic vaginal birth not achieved (CS + breech vaginal birth)… compared with no intervention of regional analgesia (with or without tocolysis) (low certainty).

• Interventions for helping to turn term breech babies to head first presentation when using external cephalic version 2015 · Cochrane Headline outcomes only
  RR 0.65 [0.47, 0.89]
  1 study · 108 participants
  Low

Rutosides vs placebo

The review found no eligible studies for this question.

• Interventions for varicose veins and leg oedema in pregnancy 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Rutosides vs placebo

Rutoside showed no clear difference in complications associated with varicose veins and leg oedema (deep… compared with placebo (moderate certainty).

• Interventions for varicose veins and leg oedema in pregnancy 2015 · Cochrane Headline outcomes only
  RR 0.17 [0.01, 3.49]
  1 study · 69 participants
  Moderate

Rutosides vs placebo

Rutoside probably leads to higher symptoms associated with varicose veins and oedema (improvement in… compared with placebo (moderate certainty).

• Interventions for varicose veins and leg oedema in pregnancy 2015 · Cochrane Headline outcomes only
  RR 1.89 [1.11, 3.22]
  1 study · 69 participants
  Moderate