Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,587 questions · 5,761 findings · 495 reviews

No studies found 1,011 · 17.5%GRADE not reported 1,797 · 31.2%Very low 1,100 · 19.1%Low 1,052 · 18.3%Moderate 649 · 11.3%High 152 · 2.6%

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5‐ASA vs placebo

Relapse, drop‐outs classed as relapse, grouped by length of · patients with maintenance of medically‐induced remission in Crohn's disease

5‐ASA showed no clear difference in relapse, drop‐outs classed as relapse, grouped by length of compared with placebo (moderate certainty).

3 findings from 1 review

Intervention not reported

Duration of diarrhoea · children with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Intervention not reported

Duration of diarrhoea · children with persistent diarrhoea

The intervention showed no clear difference in duration of diarrhoea (moderate certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea on day 7 · children with persistent diarrhoea

The intervention showed no clear difference in diarrhoea on day 7 (low certainty).

1 finding from 1 review

Intervention not reported

Hospitalization · children with persistent diarrhoea
1 finding from 1 review

Intervention not reported

Death · children with persistent diarrhoea
1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with persistent diarrhoea

It is very uncertain whether the intervention changes adverse events (vomiting) (very low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea on day 7 · children with acute diarrhoea

The intervention probably leads to lower diarrhoea on day 7 (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of children hospitalized (community trials only) · children with acute diarrhoea
1 finding from 1 review

Intervention not reported

Death · children with acute diarrhoea

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Intervention not reported

Duration of diarrhoea · children aged less than 6 months with acute diarrhoea

The intervention showed no clear difference in duration of diarrhoea (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea on day 7 · children aged less than 6 months with acute diarrhoea

The intervention showed no clear difference in diarrhoea on day 7 (low certainty).

1 finding from 1 review

Intervention not reported

Number of children hospitalized (community trials only) · children aged less than 6 months with acute diarrhoea
1 finding from 1 review

Intervention not reported

Death · children aged less than 6 months with acute diarrhoea

It is very uncertain whether the intervention changes death (very low certainty).

1 finding from 1 review