Findings

What do systematic reviews say?

4,320 questions · 4,561 findings · 388 reviews

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No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Swelling (mean) · Adults (>18 years) with established dry socket following permanent tooth extraction

The review found no eligible studies for this question.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
No studies reported this outcome
0 studies
No studies found

SaliCept (acemannan hydrogel) vs no treatment

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
SaliCept (acemannan hydrogel) versus No treatment (Kaya 2011): data not usable (medians presented with error bars). Text reports differences in clinical signs and symptoms between control and all 3 treatment groups…
1 study
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Fever · Adults (>18 years) with established dry socket following permanent tooth extraction

The review found no eligible studies for this question.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
No studies reported this outcome
0 studies
No studies found

Plasma rich in growth factors (PRGF) vs Alvogyl

Exposed bone (present versus absent) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Day 7 (also day 3)
PRGF versus Alvogyl (King 2018), exposed bone (% patients): day 3 PRGF 9.1% vs Alvogyl 9.1%; day 7 PRGF 0% vs Alvogyl 22.7% (P<0.05 at day 7)
1 study · 44 participants
GRADE not reported

Alvogyl vs SaliCept (acemannan hydrogel)

Pain (VAS) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Alvogyl versus SaliCept (acemannan hydrogel) (Kaya 2011): data not usable (medians presented with error bars). Text reports differences in clinical signs and symptoms between control and all 3 treatment groups…
1 study
GRADE not reported

Neocone vs Alvogyl

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to lower time to complete resolution of pain (days) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Complete resolution of pain
MD -1.62 [-1.86, -1.38]
1 study · 78 participants
GRADE not reported

Alvogyl vs Zinc oxide and eugenol (ZOE)

Mean time to resolution of pain · Adults (>18 years) with established dry socket following permanent tooth extraction

Alvogyl led to lower time to complete resolution of pain (days) compared with zinc oxide eugenol; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Complete resolution of pain
MD -2.17 [-2.37, -1.97]
1 study · 78 participants
GRADE not reported

P-hydroxybenzoic acid vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

P-hydroxybenzoic acid showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.08 [0.00, 1.37]
1 study · 45 participants
GRADE not reported

Heal-all tissue patch vs no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Heal-all tissue patch showed no clear difference in presence of dry socket compared with no treatment; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.08 [0.00, 1.32]
1 study · 80 participants
GRADE not reported

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
OR 0.38 [0.25, 0.58]
6 studies · 1547 participants
Moderate

Gaseous ozone vs placebo or control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Gaseous ozone showed no clear difference in presence of dry socket compared with placebo or control; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.20 [0.02, 1.61]
1 study · 60 participants
GRADE not reported

Artemisia desertorum spreng (Shahaosan) vs placebo

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Artemisia desertorum spreng (Shahaosan) showed no clear difference in presence of dry socket compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.13 [0.02, 1.02]
1 study · 188 participants
GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

Success rate (radiographically‐assessed healing of cyst healing based on the Neer/Cole rating system) · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Healing: 2 studies (Faizel 2015; Supe 2018) used different healing outcomes and could not be combined; Alvogyl appeared to heal faster than zinc oxide eugenol. Supe 2018: delayed (non-healed after 10 days) 2/25 Alvogyl…
2 studies
GRADE not reported

Alvogyl vs Platelet-rich fibrin (PRF)

Pain · Adults (>18 years) with established dry socket following permanent tooth extraction

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Alvogyl versus platelet rich fibrin (Keshini 2020): single study (30 participants); no usable pooled estimate extracted
1 study · 30 participants
GRADE not reported

Metronidazole (intrasocket) vs placebo

Duration of treatment (days) · Adults (>18 years) with established dry socket following permanent tooth extraction

Metronidazole (intrasocket) led to lower duration of treatment (days) compared with placebo; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
MD -3.17 [-5.30, -1.04]
1 study · 55 participants
GRADE not reported

Povidone iodine 1% vs control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Povidone iodine 1% led to lower presence of dry socket compared with control; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.36 [0.14, 0.98]
1 study · 189 participants
GRADE not reported

Plasma rich in growth factors (PRGF) vs Alvogyl

Pain (VAS cm) · Adults (>18 years) with established dry socket following permanent tooth extraction

Plasma rich in growth factors (PRGF) showed no clear difference in pain (VAS cm) compared with alvogyl; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Day 7 (also day 3)
MD -0.40 [-1.77, 0.97]
1 study · 44 participants
GRADE not reported

Recombinant bovine fibroblast growth factor gel vs control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Recombinant bovine fibroblast growth factor gel led to lower presence of dry socket compared with control; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.10 [0.01, 0.76]
1 study · 160 participants
GRADE not reported

Neocone vs Zinc oxide and eugenol (ZOE)

Time to initial pain relief (minutes) · Adults (>18 years) with established dry socket following permanent tooth extraction

Neocone led to lower time to initial pain relief (minutes) compared with zinc oxide eugenol; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Initial pain relief
MD -7.77 [-8.86, -6.68]
1 study · 78 participants
GRADE not reported

Platelet-rich fibrin (PRF) graft vs control

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Platelet rich fibrin showed no clear difference in presence of dry socket compared with control; GRADE not reported.

1 finding from 1 review

Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
Follow-up: median 7 days
RR 0.44 [0.15, 1.35]
1 study · 100 participants
GRADE not reported