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What do systematic reviews say?

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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Zinc vs placebo

Need for antibiotics days of antibiotic use · children with cystic fibrosis

It is very uncertain whether summary of findings: Zinc supplementation changes need for antibiotics number of days on IV or oral antibiotics compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings: garlic supplementation vs placebo

FEV1 (% predicted): mean change from baseline · children aged over eight and adults with cystic fibrosis and chronic pulmonary infection with P aeruginosa

Summary of findings: garlic supplementation showed no clear difference in respiratory function change from baseline in % predicted FEV1 compared with placebo (moderate certainty).

1 finding from 1 review