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What do systematic reviews say?

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Evidence found and GRADE certainty

4,752 questions · 6,648 findings · 688 reviews

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No studies found 1,125 · 16.9%GRADE not reported 670 · 10.1%Very low 1,796 · 27%Low 1,685 · 25.3%Moderate 1,075 · 16.2%High 297 · 4.5%

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Intervention not reported

Intervention Total studies: 9 Total participants: 883 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower intervention Total studies: 9 Total participants: 883; GRADE not reported.

1 finding from 1 review

Intervention not reported

Total studies: 30 * Total participants: 2004 No. interventions in network: 14 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 30 * Total participants: 2004 No. interventions in…; GRADE not reported.

1 finding from 1 review

Any systemic treatment vs placebo

Infliximab · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher infliximab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Tildrakizumab · people with chronic plaque psoriasis

Any systemic treatment leads to higher tildrakizumab compared with placebo (high certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Oral Tyrosine kinase 2 (TYK2) inhibitor · people with chronic plaque psoriasis

Any systemic treatment may leads to higher oral tyrosine kinase 2 (TYK2) inhibitor compared with placebo (low certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Certolizumab · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher certolizumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Ciclosporin · people with chronic plaque psoriasis

It is very uncertain whether any systemic treatment changes ciclosporin compared with placebo (very low certainty).

2 findings from 1 review