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What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

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No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

Total studies: 30 * Total participants: 2004 No. interventions in network: 14 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower total studies: 30 * Total participants: 2004 No. interventions in…; GRADE not reported.

1 finding from 1 review

Any systemic treatment vs placebo

Infliximab · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher infliximab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Tildrakizumab · people with chronic plaque psoriasis

Any systemic treatment leads to higher tildrakizumab compared with placebo (high certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Oral Tyrosine kinase 2 (TYK2) inhibitor · people with chronic plaque psoriasis

Any systemic treatment may leads to higher oral tyrosine kinase 2 (TYK2) inhibitor compared with placebo (low certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Certolizumab · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher certolizumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Ciclosporin · people with chronic plaque psoriasis

It is very uncertain whether any systemic treatment changes ciclosporin compared with placebo (very low certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Etanercept · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher etanercept compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Tofacitinib · people with chronic plaque psoriasis

Any systemic treatment may leads to higher tofacitinib compared with placebo (low certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Apremilast · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher apremilast compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Acitretin · people with chronic plaque psoriasis

It is very uncertain whether any systemic treatment changes acitretin compared with placebo (very low certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Ixekizumab · people with chronic plaque psoriasis

Any systemic treatment probably leads to higher ixekizumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Bimekizumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in bimekizumab compared with placebo (low certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Risankizumab · people with chronic plaque psoriasis

Any systemic treatment probably leads to lower risankizumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Ustekinumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in ustekinumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Guselkumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in guselkumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Adalimumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in adalimumab compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Brodalumab · people with chronic plaque psoriasis

Any systemic treatment showed no clear difference in brodalumab compared with placebo (moderate certainty).

2 findings from 1 review