Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

467 questions · 495 findings · 30 reviews · Pregnancy and Childbirth

No studies found 124 · 25.1%GRADE not reported 48 · 9.7%Very low 104 · 21%Low 134 · 27.1%Moderate 62 · 12.5%High 23 · 4.6%

Metoclopramide vs ondansetron

Intervention side effects: unable to sleep · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with ondansetron (low certainty).

1 finding from 1 review

Metoclopramide vs ondansetron

Adverse effects: dry mouth · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to higher intervention side effects: dry mouth compared with ondansetron (moderate certainty).

1 finding from 1 review

Metoclopramide vs ondansetron

Frequency of adverse effects ‐ dizziness ( · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: felt dizzy compared with ondansetron (low certainty).

1 finding from 1 review

Metoclopramide vs ondansetron

Severity, reduction or cessation in nausea/vomiting 2.Days of hospital admission 3. Pregnancy complications 4. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Metoclopramide vs promethazine

Intervention side effects: unable to sleep · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: unable to sleep compared with promethazine (low certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Frequency of adverse effects ‐ dizziness ( · Pregnant women with hyperemesis gravidarum

Metoclopramide probably leads to lower intervention side effects: felt dizzy compared with promethazine (moderate certainty).

1 finding from 1 review

Acupuncture vs placebo

Preterm birth · Pregnant women with hyperemesis gravidarum

Acupuncture showed no clear difference in preterm birth less than 37 weeks compared with placebo (low certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Gastrointestinal side effects (diarrhoea) ‐ not reported · Pregnant women with hyperemesis gravidarum

Metoclopramide showed no clear difference in intervention side effects: diarrhea compared with promethazine (low certainty).

1 finding from 1 review

Metoclopramide vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Days of hospital admission 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Ondansetron vs promethazine

Length of hospital stay · Pregnant women with hyperemesis gravidarum

It is very uncertain whether ondansetron changes days of hospital admission compared with promethazine (very low certainty).

1 finding from 1 review

Ondansetron vs promethazine

Severity, reduction or cessation in nausea/vomiting 2. Number of episodes of emesis 3. Quality of life outcomes 4. Pregnancy complications 5. Adverse fetal/neonatal outcomes · Pregnant women with hyperemesis gravidarum

The review found no eligible studies for this question.

1 finding from 1 review

Corticosteroids vs promethazine

Vomiting · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes episodes of vomiting 48 hours compared with promethazine (very low certainty).

2 findings from 1 review