Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

606 questions · 682 findings · 77 reviews

No studies found 99 · 14.5%GRADE not reported 215 · 31.5%Very low 197 · 28.9%Low 102 · 15%Moderate 48 · 7%High 21 · 3.1%

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Mortality rate and cause of death · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Any experimental intervention (surgical or non-surgical) vs None (placebo or no treatment)

Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People of any age and either sex, in any setting, with BRONJ; bisphosphonate exposure past or current; includes people with cancer and…

The review found no eligible studies for this question.

1 finding from 1 review

Glycerrhetinic acid/antibiotic mixture vs Calcium hydroxide (CH)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Ledermix (corticosteroid/antibiotic pulp-capping cement) vs Calcium hydroxide (CH)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Ledermix (corticosteroid/antibiotic pulp-capping cement) vs Glycerrhetinic acid/antibiotic mixture

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Potassium nitrate/polycarboxylate cement (KNO3/PCa)

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 9/17 in the KNO3/PCa group; symptomatic teeth required endodontic therapy or extraction.…
    1 study · 35 participants
    GRADE not reported

Calcium hydroxide (CH) vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Potassium nitrate/dimethyl isosorbide/polycarboxylate cement (KNO3/DMI/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 10/12 in the PCa group. "The results in groups two and three were statistically…
    1 study · 30 participants
    GRADE not reported

Glycerrhetinic acid/antibiotic mixture vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported

Potassium nitrate/polycarboxylate cement (KNO3/PCa) vs Polycarboxylate cement (PCa) alone

Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Hodosh 2003 (Analysis 3.1): 9/17 in the KNO3/PCa group and 10/12 in the PCa group developed clinical symptoms requiring endodontic therapy or extraction. No significance test reported for this specific contrast; no…
    1 study · 29 participants
    GRADE not reported

Ledermix (corticosteroid/antibiotic pulp-capping cement) vs Zinc oxide and eugenol (ZOE)

Clinical success (survival free of symptoms) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
  • Shovelton 1971 (Analysis 1.1): 275 teeth followed for 2 years (235 at 6 months, 160 at 12 months, 85 analysed at 24 months). Success rates 50% to 80%. Ledermix and calcium hydroxide had the highest success rates,…
    1 study · 275 participants
    GRADE not reported