Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,476 questions · 1,535 findings · 101 reviews

No studies found 233 · 15.2%GRADE not reported 332 · 21.6%Very low 209 · 13.6%Low 343 · 22.3%Moderate 279 · 18.2%High 139 · 9.1%

Intervention not reported

Chemobased OS ‐ 5‐FU based chemotherapy OS · patients with resectable gastric cancer

The intervention probably leads to lower chemobased OS ‐ 5‐FU based chemotherapy OS (moderate certainty).

1 finding from 1 review

Intervention not reported

Chemobased OS ‐ Platinum‐based chemotherapy OS · patients with resectable gastric cancer

The intervention showed no clear difference in chemobased OS ‐ Platinum‐based chemotherapy OS (moderate certainty).

1 finding from 1 review

Intervention not reported

Chemobased DFS ‐ 5‐FU based chemotherapy DFS · patients with resectable gastric cancer

The intervention probably leads to lower chemobased DFS ‐ 5‐FU based chemotherapy DFS (moderate certainty).

1 finding from 1 review

Intervention not reported

Chemobased DFS ‐ Platinum‐based chemotherapy DFS · patients with resectable gastric cancer

The intervention showed no clear difference in chemobased DFS ‐ Platinum‐based chemotherapy DFS (moderate certainty).

1 finding from 1 review

Altered fractionation radiotherapy plus chemotherapy vs Chemoradiotherapy with standard (conventional) fractionation

Outcome not reported · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

The review found no eligible studies for this question.

1 finding from 1 review

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) vs ADT only

Death (all causes)

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) probably leads to lower time to death due to any cause (absolute effect size estimates based… compared with ADT only (moderate certainty).

1 finding from 1 review

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) vs ADT only

Time to progression

Early taxane‐based chemotherapy and androgen deprivation therapy (ADT) probably leads to lower time to progression (absolute effect size estimates based on… compared with ADT only (moderate certainty).

1 finding from 1 review

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Interruptions to cancer treatment (chemotherapy delays/discontinuations) · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in interruptions to cancer treatment (chemotherapy… compared with placebo; GRADE not reported.

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (binary outcome) All‐cause mortality for the duration of · patients with oesophageal cancer

Non‐surgical showed no clear difference in long‐term mortality (binary): definitive chemoradiotherapy versus… compared with surgical treatment of oesophageal cancer (primary outcomes) (low certainty).

1 finding from 1 review

Non‐surgical vs surgical treatment of oesophageal cancer (primary outcomes)

Long‐term mortality (time‐to‐event outcome): chemoradiotherapy versus surgery All‐cause mortality for the duration of · patients with oesophageal cancer

It is very uncertain whether non‐surgical changes long‐term mortality (time‐to‐event): definitive chemoradiotherapy… compared with surgical treatment of oesophageal cancer (primary outcomes) (very low certainty).

1 finding from 1 review

Rapid COJEC vs standard induction therapies

Early toxicities (during preoperative chemotherapy): febrile neutropenia (2 or more episodes), proven fungal infections, septicemia (1 or more episodes), gastrointestinal toxicity (grade 3 or 4), renal toxicity (glomerular filtration rate < 80 ml/... · patients with high‐risk neuroblastoma
1 finding from 1 review

Intervention not reported

the toxic and side effects in digestive system after chemotherapy (no special data in trial of Zhang 2006) · patients with induction of remission in advanced or late gastric cancer

It is very uncertain whether the intervention changes the toxic and side effects in digestive system after chemotherapy… (very low certainty).

1 finding from 1 review

Intervention not reported

the toxic and side effects in digestive system after chemotherapy · patients with induction of remission in advanced or late gastric cancer

It is very uncertain whether the intervention changes the toxic and side effects in digestive system after chemotherapy (very low certainty).

1 finding from 1 review