Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

236 questions · 242 findings · 34 reviews · Headline outcomes only

No studies found 85 · 35.1%GRADE not reported 4 · 1.7%Very low 58 · 24%Low 52 · 21.5%Moderate 36 · 14.9%High 7 · 2.9%

Zinc vs placebo

QoL of participants living with SCD and their caregivers · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Zinc vs placebo

Frequency of sickle cell‐related complications: number of participants with completely healed leg ulcer ( · people with sickle cell disease

It is very uncertain whether zinc changes frequency of sickle cell‐related complications: number of… compared with placebo (very low certainty).

1 finding from 1 review

Zinc vs placebo

Frequency of crisis · people with sickle cell disease

Zinc showed no clear difference in frequency of crisis compared with placebo (low certainty).

1 finding from 1 review