Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

355 questions · 361 findings · 45 reviews

No studies found 99 · 27.4%GRADE not reported 86 · 23.8%Very low 74 · 20.5%Low 55 · 15.2%Moderate 40 · 11.1%High 7 · 1.9%

Zinc vs placebo

QoL of participants living with SCD and their caregivers · people with sickle cell disease

The review found no eligible studies for this question.

1 finding from 1 review

Zinc vs placebo

Frequency of sickle cell‐related complications: number of participants with completely healed leg ulcer ( · people with sickle cell disease

It is very uncertain whether zinc changes frequency of sickle cell‐related complications: number of… compared with placebo (very low certainty).

1 finding from 1 review

Zinc vs placebo

Frequency of crisis · people with sickle cell disease

Zinc showed no clear difference in frequency of crisis compared with placebo (low certainty).

1 finding from 1 review