Findings

What do systematic reviews say?

23 questions · 23 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 5 · 21.7%Very low 6 · 26.1%Low 4 · 17.4%Moderate 8 · 34.8%High 0 · 0%

Valaciclovir (suppressive regimen vs episodic regimen)

Severity of attack of recurrent herpes labialis during use of the preventative intervention (maximum lesion area) · participants with recurrent herpes labialis

1 finding from 1 review

Interventions for prevention of herpes simplex labialis (cold sores on the lips) 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 120 participants
Very low

Prophylactic aciclovir (oral or intravenous) vs Prophylactic valaciclovir (oral)

Presence/absence of HSV oral lesions · Patients being treated for cancer (predominantly haematological malignancies)

Prophylactic aciclovir (oral or intravenous) showed no clear difference in presence/absence of HSV oral lesions compared with prophylactic valaciclovir (oral); GRADE not reported.

1 finding from 1 review

Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
RR 0.78 [0.26, 2.38]
2 studies · 181 participants
GRADE not reported

Prophylactic aciclovir (oral or intravenous) vs Prophylactic valaciclovir (oral)

Cost of oral care · Patients being treated for cancer (predominantly haematological malignancies)

1 finding from 1 review

Interventions for the prevention and treatment of herpes simplex virus in patients being treated for cancer 2009 · Cochrane All outcomes
Only one trial reported on the cost of prophylaxis for HSV (Liesveld 2002). The reported mean pharmacy costs for those randomised to receive aciclovir were $1080 compared to $320 for those initially randomised to…
1 study · 30 participants
GRADE not reported