Findings

What do systematic reviews say?

22 questions · 23 findings · 4 reviews

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No studies found 0 · 0%GRADE not reported 1 · 4.3%Very low 6 · 26.1%Low 7 · 30.4%Moderate 9 · 39.1%High 0 · 0%

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Breast Cancer‐related Death · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in breast cancer‐related death compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

Levonorgestrel intrauterine system for endometrial protection in women with breast cancer on adjuvant tamoxifen 2020 · Cochrane Headline outcomes only
OR 1.02 [0.36, 2.84]
3 studies · 277 participants
Moderate

Aromatase inhibitors vs tamoxifen (indirect comparison)a

Overall breast cancer incidence · women with above‐average risk of developing breast cancer

Aromatase inhibitors may leads to lower overall breast cancer incidence compared with tamoxifen (indirect comparison)a (low certainty).

1 finding from 1 review

Risk‐reducing medications for primary breast cancer: a network meta‐analysis 2019 · Cochrane Headline outcomes only
RR 0.67 [0.46, 0.98]
5 studies · 31256 participants
Low