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Evidence found and GRADE certainty

24 questions · 28 findings · 4 reviews · Skin

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No studies found 8 · 28.6%GRADE not reported 3 · 10.7%Very low 2 · 7.1%Low 2 · 7.1%Moderate 12 · 42.9%High 1 · 3.6%

Tacrolimus 0.1% vs vehicle

Primary: adverse events ‐ burning/itching at application site · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

Topical calcineurin inhibitors: tacrolimus 0.1% ointment showed no clear difference in primary: adverse events ‐ burning/itching at application site compared with vehicle (moderate certainty).

1 finding from 1 review

Tacrolimus 0.1% vs vehicle

Secondary: investigator‐rated reduction in severity ‐ Not measured · people with moderate to severe nickel sulphate‐induced allergic contact dermatitis based on clinical history (hand eczema) and proven by…

The review found no eligible studies for this question.

1 finding from 1 review

Tacrolimus 0.03% vs Topical tacrolimus

Physician's assessment of global response of improvement · people with atopic dermatitis

Tacrolimus 0.03% leads to lower physician's assessment of global response of improvement, clear or… compared with tacrolimus 0.1% (high certainty).

1 finding from 1 review