Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 45 findings · 4 reviews · Stroke

No studies found 10 · 22.2%GRADE not reported 0 · 0%Very low 3 · 6.7%Low 17 · 37.8%Moderate 14 · 31.1%High 1 · 2.2%

tDCS vs placebo or control

Dropouts, adverse events and deaths during intervention phase Numbers of dropouts, adverse events and deaths from all causes · people with stroke

tDCS showed no clear difference in secondary outcome measure: dropouts, adverse events and deaths… compared with any type of placebo or passive control intervention (moderate certainty).

1 finding from 1 review

TDC vs medical therapy

Primary outcome measure: composite of recurrent stroke (non‐fatal or fatal) or transient ischemic attack (TIA) · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: composite of recurrent stroke (non‐fatal or… compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Time‐to‐event analyses for composite of recurrent stroke or TIA · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in time‐to‐event analyses for composite of recurrent stroke or TIA compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Time‐to‐event analyses for composite of recurrent stroke or TIA stratified by the type of device studied ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in time‐to‐event analyses for composite of recurrent stroke or TIA… compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Primary outcome measure: composite of recurrent stroke (non‐fatal or fatal) or transient ischemic attack (TIA) stratified by the type of device ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: composite of recurrent stroke (non‐fatal or… compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Recurrent events: fatal or non‐fatal (same type of stroke, i.e. ischaemic or haemorrhagic) · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: recurrent stroke (non‐fatal or fatal) compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Primary outcome measure: recurrent stroke (non‐fatal or fatal) stratified by the type of device studied ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in primary outcome measure: recurrent stroke (non‐fatal or fatal)… compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Death from any cause (secondary outcome 3) · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in secondary outcome: all‐cause mortality at the end of compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Secondary outcome:total serious adverse events at the end of · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in secondary outcome:total serious adverse events at the end of compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Secondary outcome: the incidence of atrial fibrillation · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC probably leads to higher secondary outcome: the incidence of atrial fibrillation compared with medical therapy (moderate certainty).

1 finding from 1 review

TDC vs medical therapy

Time‐to‐event analyses for recurrent stroke · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in time‐to‐event analyses for recurrent stroke compared with medical therapy (low certainty).

1 finding from 1 review

TDC vs medical therapy

Time‐to‐event analyses for recurrent stroke stratified by the type of device ‐ Amplatzer PFO occluder · people with patent foramen ovale and a history of cryptogenic stroke or transient ischemic attack

TDC showed no clear difference in time‐to‐event analyses for recurrent stroke stratified by the type… compared with medical therapy (moderate certainty).

1 finding from 1 review

tDCS plus speech and language therapy (SLT) vs sham tDCS plus SLT

Functional communication · patients with improving aphasia in patients with aphasia after stroke
2 findings from 1 review

tDCS plus speech and language therapy (SLT) vs sham tDCS plus SLT

Language impairment: accuracy of naming nouns at · patients with improving aphasia in patients with aphasia after stroke
2 findings from 1 review