Findings

What do systematic reviews say?

45 questions · 45 findings · 3 reviews · Periodontology

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No studies found 6 · 13.3%GRADE not reported 29 · 64.4%Very low 6 · 13.3%Low 3 · 6.7%Moderate 1 · 2.2%High 0 · 0%

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Attachment change · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
Reported as a secondary periodontal outcome (Analysis 1.7); results not meta-analysed due to considerable heterogeneity (I2 91% to 100%); reduction in favour of periodontal treatment.
4 studies
GRADE not reported

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Change in probing pocket depth (PPD) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
Reported as a secondary periodontal outcome (Analysis 1.6); results not meta-analysed due to considerable heterogeneity (I2 91% to 100%); reduction in favour of periodontal treatment.
4 studies
GRADE not reported

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Small‐for‐gestational age · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, polishing, or… showed no clear difference in small for gestational age compared with no treatment (low certainty).

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
RR 0.97 [0.81, 1.16]
3 studies · 3610 participants
Low

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Low birth weight (< 2.5 kg) · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

Periodontal treatment (scaling and root planing, polishing, or… may leads to lower birth weight (low birth weight < 2500 g) compared with no treatment (low certainty).

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
RR 0.67 [0.48, 0.95]
7 studies · 3470 participants
Low

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Maternal death · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
0% in both groups; Not estimated; 2134 participants (4 RCTs)
4 studies · 2134 participants
GRADE not reported

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Plaque index (PI) / oral hygiene · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
Reported as a secondary periodontal outcome (Analysis 1.8); results not meta-analysed due to considerable heterogeneity (I2 91% to 100%); reduction in favour of periodontal treatment.
2 studies
GRADE not reported

Periodontal treatment (scaling and root planing, polishing, or surgery), alone or with oral hygiene counselling, antiseptics, or antimicrobials vs no treatment

Pre‐eclampsia · Pregnant women considered to have periodontal disease (gingivitis or periodontitis) after dental examination

It is very uncertain whether periodontal treatment (scaling and root planing, polishing, or… changes pre-eclampsia compared with no treatment (very low certainty).

1 finding from 1 review

Treating periodontal disease for preventing adverse birth outcomes in pregnant women 2017 · Cochrane All outcomes
RR 1.10 [0.74, 1.62]
3 studies · 2946 participants
Very low

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Sites failing to gain 2 mm attachment (proportion) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to lower sites failing to gain 2 mm attachment (proportion) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
RR 0.54 [0.31, 0.96]
6 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Aesthetics · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

The review found no eligible studies for this question.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
0 studies
No studies found

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Change in gingival recession (REC) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in gingival recession compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
MD 0.26 [0.08, 0.43]
9 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Treatment / surgical procedure time · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… showed no clear difference in treatment / surgical procedure time compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
MD 23.9
1 study
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Attachment change · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in clinical attachment level (attachment gain) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
MD 1.22 [0.80, 1.64]
16 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Hard tissue probing at surgical re-entry (bone gain) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
MD 1.39 [1.08, 1.71]
3 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Cost/benefit (treatment time plus estimated material costs) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

The review found no eligible studies for this question.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
0 studies
No studies found

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Hard tissue probing at surgical re-entry (bone gain) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher hard tissue probing at surgical re-entry (bone gain) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
MD 3.37 [3.14, 3.61]
1 study
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Radiographic bone change · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
Radiographic data was contained in two studies. Mayfield 1998 showed 0.6 mm gain in bone from the base of the defect in both test and control groups; Ratka-Kruger 2000 reported descriptively that only minute changes in…
2 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Tooth loss · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
No tooth loss was reported in any study although these data are incomplete where patient follow-up was not complete (no events; no estimable effect).
17 studies
GRADE not reported

GTR rm associated with bone substitutes vs Open flap debridement (access flap surgery)

Attachment change · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) combined with bone substitutes/graft led to higher change in clinical attachment level (attachment gain) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
MD 1.25 [0.89, 1.61]
2 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Change in probing pocket depth (PPD) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

Guided tissue regeneration (GTR) with barrier membrane (resorbable… led to higher change in probing depth (probing depth reduction) compared with open flap debridement (access flap surgery); GRADE not reported.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
>=12 months
MD 1.21 [0.53, 1.88]
11 studies
GRADE not reported

Guided tissue regeneration (GTR) with barrier membrane (resorbable or non-resorbable) vs Open flap debridement (access flap surgery)

Disease recurrence (% sites with >=2 mm loss of probing attachment from 12 months after treatment) · Patients with chronic periodontitis (aged 21 years or older) with periodontal infra-bony defects; furcation-involved teeth and aggressive…

The review found no eligible studies for this question.

1 finding from 1 review

Guided tissue regeneration for periodontal infra-bony defects 2006 · Cochrane All outcomes
No data were found for this outcome (listed under 'Other outcomes: No data were found for the following outcomes').
0 studies
No studies found