Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

174 questions · 184 findings · 7 reviews · Metabolic and Endocrine Disorders

No studies found 56 · 30.4%GRADE not reported 2 · 1.1%Very low 51 · 27.7%Low 62 · 33.7%Moderate 13 · 7.1%High 0 · 0%

Insulin glargine vs NPH insulin

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

Summary of findings: insulin glargine showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).

1 finding from 1 review

Summary of findings: insulin degludec vs insulin detemir

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)

Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin detemir (low certainty).

1 finding from 1 review

Summary of findings: insulin degludec vs insulin glargine

Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring from 22:00 to 06:59 h

Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (low certainty).

1 finding from 1 review