What do systematic reviews say?

Antacids vs sucralfate

Antacids showed no clear difference in clinically important upper GI bleeding compared with sucralfate (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1 [0.72, 1.39]
  16 studies · 1772 participants
  Low

Antacids vs sucralfate

Antacids showed no clear difference in nosocomial pneumonia compared with sucralfate (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.04 [0.84, 1.3]
  7 studies · 996 participants
  Low

Antacids vs sucralfate

Antacids showed no clear difference in all‐cause mortality in ICU compared with sucralfate (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.15 [0.93, 1.4]
  11 studies · 1249 participants
  Low

Antacids vs sucralfate

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 227 participants
  Low

Antacids vs sucralfate

Antacids showed no clear difference in number of participants requiring blood transfusion compared with sucralfate (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 0.73 [0.4, 1.34]
  6 studies · 667 participants
  Low

Antacids vs sucralfate

The review found no eligible studies for this question.

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found