Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 151 findings · 21 reviews

No studies found 23 · 15.2%GRADE not reported 19 · 12.6%Very low 32 · 21.2%Low 35 · 23.2%Moderate 28 · 18.5%High 14 · 9.3%

Statins vs control

Early all‐cause mortality (≤ 3 months) Reported at: 28 days; 60 days; and during hospital stay · adults with acute respiratory distress syndrome

Statins showed no clear difference in early all‐cause mortality (≤ 3 months) Reported at: 60 days; and… compared with control (moderate certainty).

1 finding from 1 review

Statins plus beta interferon vs interferon beta‐1a

Relapse · Multiple sclerosis

It is very uncertain whether statins plus beta interferon changes number of participants with relapses at 12 months Number of… compared with beta interferon (very low certainty).

2 findings from 1 review

Statins plus beta interferon vs interferon beta‐1a

Number of participants with progression at 24 months Number of participants with progression at 24 months · Multiple sclerosis

It is very uncertain whether statins plus beta interferon changes number of participants with progression at 24 months Number of… compared with beta interferon (very low certainty).

1 finding from 1 review

Statins plus beta interferon vs interferon beta‐1a

Number of participants with new T2 or GELs at 12 months Number of participants with new T2 or GELs at 12 months · Multiple sclerosis

It is very uncertain whether statins plus beta interferon changes number of participants with new T2 or GELs at 12 months Number of… compared with beta interferon (very low certainty).

1 finding from 1 review