Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

57 questions · 58 findings · 4 reviews · Eyes and Vision

No studies found 14 · 24.1%GRADE not reported 1 · 1.7%Very low 5 · 8.6%Low 15 · 25.9%Moderate 21 · 36.2%High 2 · 3.4%

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to geographic atrophy · people with AMD

Antioxidant multivitamin and mineral supplement showed no clear difference in progression to geographic atrophy compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antioxidant multivitamin and mineral supplement vs placebo or no treatment

Progression to visual loss (loss of 3 or more lines on logMAR chart) · people with AMD

Antioxidant multivitamin and mineral supplement probably leads to lower progression to visual loss (loss of 3 or more lines on logMAR chart) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Lutein with or without zeaxanthin vs placebo

Progression to late AMD (neovascular AMD, geographic atrophy or both) · people with AMD

Lutein with or without zeaxanthin showed no clear difference in progression to late AMD (neovascular AMD, geographic atrophy, or both) compared with placebo (low certainty).

1 finding from 1 review

Iridotomy vs no iridotomy

Need for additional surgery: proportion of participants who received additional surgery to control IOP at 1 year · people with primary angle‐closure suspect

Iridotomy showed no clear difference in need for additional surgery: proportion of participants who received… compared with no iridotomy (low certainty).

1 finding from 1 review

Intervention not reported

Undercorrected vs fully corrected spectacles · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Systemic 7‐methylxanthine vs placebo · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus multifocal spectacles vs placebo plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Atropine plus bifocal spectacles vs cyclopentolate plus SVLs · children with myopia (nearsightedness)
1 finding from 1 review