Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

69 questions · 69 findings · 7 reviews · Emergency and Critical Care

No studies found 19 · 27.5%GRADE not reported 2 · 2.9%Very low 14 · 20.3%Low 15 · 21.7%Moderate 18 · 26.1%High 1 · 1.4%

Intravenous midazolam vs placebo

Anterograde amnesia (defined by number of participants who recalled the procedure) · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs placebo

Allergic or anaphylactoid reaction · adults requiring sedation before gastrointestinal endoscopy and bronchoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Incomplete procedure · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

Oral midazolam probably leads to higher incomplete procedures compared with chloral hydrate (moderate certainty).

1 finding from 1 review

Oral midazolam vs chloral hydrate

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Disinhibition or excitation · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Intravenous midazolam vs diazepam

Anxiety · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy

Intravenous midazolam showed no clear difference in numeric rating of anxiety or rated as anxious compared with diazepam (low certainty).

1 finding from 1 review

Oral midazolam vs chloral hydrate

Patient discomfort · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs chloral hydrate

Allergic or anaphylactoid reaction · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Anxiety · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Incomplete procedure · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Anterograde amnesia (defined by number of participants who recalled the procedure) · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Disinhibition or excitation · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review

Oral midazolam vs placebo

Discomfort/pain · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy
1 finding from 1 review

Oral midazolam vs placebo

Allergic or anaphylactoid reaction · children requiring sedation before micturating cystourethrograms and Kirschner wire removal and adults undergoing flexible sigmoidoscopy

The review found no eligible studies for this question.

1 finding from 1 review