Hypoglycaemia requiring third‐party assistance median · people with diabetes and CKD
Sodium‐glucose co‐transporter protein 2 (SGLT2) inhibitors leads to lower hypoglycaemia requiring third‐party assistance median compared with placebo (high certainty).
1 finding from 1 review
Diabetic ketoacidosis median · people with diabetes and CKD
Sodium‐glucose co‐transporter protein 2 (SGLT2) inhibitors probably leads to higher diabetic ketoacidosis median compared with placebo (moderate certainty).
1 finding from 1 review
Cardiovascular mortality · CVD (ASCVD, HF, or both)
SGLT2i probably leads to lower cardiovascular mortality compared with placebo (moderate certainty).
1 finding from 1 review
Fatal or nonfatal myocardial infarction · CVD (ASCVD, HF, or both)
SGLT2i showed no clear difference in myocardial infarction (fatal or non‐fatal) compared with placebo (high certainty).
1 finding from 1 review
Fatal or nonfatal stroke · CVD (ASCVD, HF, or both)
SGLT2i showed no clear difference in stroke (fatal or non‐fatal) compared with placebo (moderate certainty).
1 finding from 1 review
All‐cause mortality · CVD (ASCVD, HF, or both)
SGLT2i probably leads to lower all‐cause mortality compared with placebo (moderate certainty).
1 finding from 1 review
Heart failure hospitalisation (RR) · CVD (ASCVD, HF, or both)
SGLT2i leads to lower hospitalisation for HF compared with placebo (high certainty).
1 finding from 1 review
Worsening kidney function · CVD (ASCVD, HF, or both)
SGLT2i probably leads to lower worsening renal function compared with placebo (moderate certainty).
1 finding from 1 review
Hypoglycaemia · CVD (ASCVD, HF, or both)
SGLT2i showed no clear difference in hypoglycaemia compared with placebo (moderate certainty).
1 finding from 1 review
Pancreatitis · CVD (ASCVD, HF, or both)
SGLT2i showed no clear difference in pancreatitis compared with placebo (low certainty).
1 finding from 1 review
Fracture · CVD (ASCVD, HF, or both)
SGLT2i showed no clear difference in fracture compared with placebo (high certainty).
1 finding from 1 review