Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

50 questions · 51 findings · 10 reviews · Headline outcomes only

No studies found 8 · 15.7%GRADE not reported 4 · 7.8%Very low 24 · 47.1%Low 12 · 23.5%Moderate 3 · 5.9%High 0 · 0%

PIMOZIDE vs antipsychotics

Adverse effects: extrapyramidal adverse effectsParkinsonism (rigidity) short term (< 3 months) Clinical diagnoses · patients with schizophrenia or related psychoses

PIMOZIDE showed no clear difference in adverse effects: extrapyramidal adverse effectsParkinsonism… compared with ANY ANTIPSYCHOTIC (low certainty).

1 finding from 1 review

PIMOZIDE vs placebo

Adverse effects: extrapyramidal adverse effects Parkinsonism (rigidity) short term (< 3 months) Extrapyramidal Symptom Rating Scale (ESRS) · patients with schizophrenia or related psychoses

It is very uncertain whether PIMOZIDE changes adverse effects: extrapyramidal adverse effects: Parkinsonism… compared with PLACEBO (very low certainty).

1 finding from 1 review

PIMOZIDE vs placebo

Adverse effects: extrapyramidal adverse effects Parkinsonism (rigidity) medium term (3‐12 months) Clinical diagnoses · patients with schizophrenia or related psychoses

It is very uncertain whether PIMOZIDE changes adverse effects: extrapyramidal adverse effects:Parkinsonism… compared with PLACEBO (very low certainty).

1 finding from 1 review

Soft cup vs rigid cup

Failed delivery with allocated instrument (primary) · Women in the second stage of labour, requiring an assisted vaginal birth

Soft cup may leads to higher failed delivery with allocated instrument (primary) compared with rigid cup (low certainty).

1 finding from 1 review

Soft cup vs rigid cup

Any maternal trauma (primary) · Women in the second stage of labour, requiring an assisted vaginal birth

Soft cup showed no clear difference in any maternal trauma (primary) compared with rigid cup (low certainty).

1 finding from 1 review

Soft cup vs rigid cup

Third‐ or fourth‐degree perineal tear (with or without episiotomy) · Women in the second stage of labour, requiring an assisted vaginal birth

Soft cup showed no clear difference in third‐ or fourth‐degree perineal tear (with or without episiotomy) compared with rigid cup (low certainty).

1 finding from 1 review

Soft cup vs rigid cup

Postpartum haemorrhage · Women in the second stage of labour, requiring an assisted vaginal birth

Soft cup showed no clear difference in postpartum haemorrhage (≥ 500 mL or as defined by trial authors) compared with rigid cup (moderate certainty).

1 finding from 1 review

Soft cup vs rigid cup

Low Apgar score · Women in the second stage of labour, requiring an assisted vaginal birth

Soft cup showed no clear difference in low Apgar score at 5 minutes (less than 7 or as defined by trial… compared with rigid cup (low certainty).

1 finding from 1 review

Soft cup vs rigid cup

Low umbilical artery pH (< 7.2 or as defined by trial authors) · Women in the second stage of labour, requiring an assisted vaginal birth

Soft cup showed no clear difference in low umbilical artery pH (< 7.2 or as defined by trial authors) compared with rigid cup (low certainty).

1 finding from 1 review