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What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 28 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 3 · 10.7%Very low 4 · 14.3%Low 9 · 32.1%Moderate 9 · 32.1%High 3 · 10.7%

Single inhaler therapy vs fixed dose ICS

Hospital admissions due to exacerbations: number of participants · adults with asthma not well controlled on ICS

Single inhaler therapy showed no clear difference in patients with exacerbations causing hospitalisation compared with fixed dose ICS (moderate certainty).

1 finding from 1 review

Single inhaler therapy vs fixed dose ICS

Rate of exacerbations requiring systemic corticosteroids · adults with asthma not well controlled on ICS

Single inhaler therapy leads to lower patients with exacerbations treated with oral steroids compared with fixed dose ICS (high certainty).

1 finding from 1 review