What do systematic reviews say?

Prophylactic CPAP vs mechanical ventilation

Prophylactic CPAP showed no clear difference in death Death at any time compared with mechanical ventilation (moderate certainty).

• Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
  RR 0.82 [0.66, 1.03]
  3 studies · 2358 participants
  Moderate