Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

461 questions · 472 findings · 42 reviews · Neuromuscular

No studies found 93 · 19.7%GRADE not reported 81 · 17.2%Very low 99 · 21%Low 103 · 21.8%Moderate 75 · 15.9%High 21 · 4.4%

IVIg vs placebo

Proportion of participants in which at least 1 conduction block resolved after therapy · people with multifocal motor neuropathy

IVIg showed no clear difference in proportion of participants in which at least 1 conduction block… compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo

Proportion of IVIg‐treated participants with an increase in disability during controlled IVIg withdrawal · people with multifocal motor neuropathy

IVIg probably leads to higher proportion of IVIg‐treated participants with an increase in… compared with placebo (moderate certainty).

1 finding from 1 review

IVIg vs placebo

Proportion of IVIg‐treated participants with a decrease in muscle strength during controlled IVIg withdrawal · people with multifocal motor neuropathy

IVIg probably leads to lower proportion of IVIg‐treated participants with a decrease in muscle… compared with placebo (moderate certainty).

1 finding from 1 review

IVIg vs placebo

Proportion of participants with side effects attributable to treatment · people with multifocal motor neuropathy

It is very uncertain whether IVIg changes proportion of participants with side effects attributable to treatment compared with placebo (very low certainty).

1 finding from 1 review

Botulinum toxin vs placebo

Participant‐reported improvement in sialorrhea in the short term · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

Botulinum toxin injection showed no clear difference in participant‐reported improvement in sialorrhea in the short term… compared with placebo (low certainty).

1 finding from 1 review