Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

191 questions · 225 findings · 21 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 50 · 22.2%GRADE not reported 8 · 3.6%Very low 62 · 27.6%Low 55 · 24.4%Moderate 38 · 16.9%High 12 · 5.3%

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

Overall survival (OS) · newly‐diagnosed EOC

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy showed no clear difference in overall survival (OS) compared with placebo (maintenance therapy) (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy vs placebo (maintenance therapy)

Progression‐free survival · newly‐diagnosed EOC

Summary of findings table ‐ Newly‐diagnosed EOC: PARPi monotherapy may leads to lower progression‐free survival (PFS) compared with placebo (maintenance therapy) (low certainty).

1 finding from 1 review