Phenobarbital vs chlorpromazine
Adverse events To discharge · newborn infants with opioid withdrawal
1 finding from 1 review
- no estimate extracted1 study · 100 participantsLow
Findings
What do systematic reviews say?
84 questions · 84 findings · 4 reviews · Neonatal
No studies found 27 · 32.1%GRADE not reported 1 · 1.2%Very low 35 · 41.7%Low 18 · 21.4%Moderate 3 · 3.6%High 0 · 0%
Phenobarbital vs supportive care
Neonatal or infant mortality · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Phenobarbital vs supportive care
Neurodevelopmental disability · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Phenobarbital vs supportive care
Length of hospital stay · newborn infants with opioid withdrawal
1 finding from 1 review
- no estimate extracted1 study · 62 participantsVery low
Phenobarbital vs supportive care
Days' pharmacological treatment · newborn infants with opioid withdrawal
1 finding from 1 review
- no estimate extracted1 study · 62 participantsVery low
Phenobarbital vs supportive care
Adverse events To discharge · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Phenobarbital vs diazepam
Treatment failure To discharge · newborn infants with opioid withdrawal
Phenobarbital may leads to lower treatment failure To discharge compared with diazepam (low certainty).
1 finding from 1 review
- RR 0.39 [0.24, 0.62]2 studies · 139 participantsLow
Phenobarbital vs diazepam
Seizures To discharge · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures
Summary of findings table ‐ Phenobarbital + bumetanide showed no clear difference in proportion of infants who achieve seizure control after the first… compared with phenobarbital alone (low certainty).
1 finding from 1 review
- RR 0.95 [0.37, 2.4]1 study · 43 participantsLow
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Proportion of infants who achieve seizure control after maximal loading dose of ASM · neonates with EEG‐confirmed seizures
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Mortality or neurodevelopmental disability at 18 to 24 months' corrected age ‐ not reported · neonates with EEG‐confirmed seizures
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Mortality before hospital discharge · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes mortality before hospital discharge compared with phenobarbital alone (very low certainty).
1 finding from 1 review
- RR 0.2 [0.02, 1.74]1 study · 43 participantsVery low
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Cognitive impairment · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes cognitive impairment at 18‐24 months compared with phenobarbital alone (very low certainty).
1 finding from 1 review
- RR 0.53 [0.13, 2.15]1 study · 29 participantsVery low
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Need for mechanical ventilation · neonates with EEG‐confirmed seizures
1 finding from 1 review
- no estimate extracted1 study · 1 participantsGRADE not reported
Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital
Proportion of infants who develop epilepsy post‐discharge · neonates with EEG‐confirmed seizures
It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes proportion of infants who develop epilepsy post‐discharge compared with phenobarbital alone (very low certainty).
1 finding from 1 review
- RR 1.13 [0.43, 2.97]1 study · 39 participantsVery low
Phenobarbital and opioid vs opioid
Treatment failure To discharge · newborn infants with opioid withdrawal
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Phenobarbital and opioid vs opioid
Seizures To discharge · newborn infants with opioid withdrawal
1 finding from 1 review
- no estimate extracted1 study · 20 participantsVery low
Phenobarbital and opioid vs opioid
Neonatal or infant mortality · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Phenobarbital and opioid vs opioid
Neurodevelopmental disability · newborn infants with opioid withdrawal
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Phenobarbital and opioid vs opioid
Length of hospital stay · newborn infants with opioid withdrawal
1 finding from 1 review
- no estimate extracted1 study · 20 participantsLow