Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

54 questions · 60 findings · 6 reviews

No studies found 12 · 20%GRADE not reported 0 · 0%Very low 15 · 25%Low 16 · 26.7%Moderate 13 · 21.7%High 4 · 6.7%

Ultrasound guidance vs no ultrasound

Minor complications (3 to 6 weeks · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

Ultrasound guidance showed no clear difference in minor complications compared with no ultrasound guidance (low certainty).

1 finding from 1 review

Ultrasound guidance vs no ultrasound

Major complications · children (≤ 18 years of age) undergoing any type of surgical procedure (open or laparoscopic) for which a neuraxial (spinal, epidural,…

Ultrasound guidance showed no clear difference in major complications compared with no ultrasound guidance (moderate certainty).

1 finding from 1 review

Intravenous dexamethasone vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Perineural vs intravenous dexamethasone

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review

Perineural vs intravenous dexamethasone

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · peripheral nerve block
3 findings from 1 review

Perineural dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block
1 finding from 1 review

Perineural dexamethasone vs placebo

Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review

Intravenous dexamethasone vs placebo

Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Pain on movement at 30 minutes after block placement · patients with hip fracture
1 finding from 1 review

Intervention not reported

Cost of analgesic regimens for single‐injection blocks · patients with hip fracture
1 finding from 1 review

Epidural analgesia vs peripheral nerve blocks

Duration of tracheal intubation · adults undergoing cardiac surgery without cardiopulmonary bypass

It is very uncertain whether epidural analgesia changes duration of tracheal intubation compared with peripheral nerve blocks (very low certainty).

1 finding from 1 review

Epidural analgesia vs peripheral nerve blocks

Pain at rest at 6 to 8 hours (score from 0 to 10) · adults undergoing cardiac surgery without cardiopulmonary bypass

It is very uncertain whether epidural analgesia changes pain at rest at 6 to 8hours after surgery (score from 0 to 10) compared with peripheral nerve blocks (very low certainty).

1 finding from 1 review