Findings

What do systematic reviews say?

24 questions · 24 findings · 1 reviews · Eyes and Vision

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No studies found 5 · 20.8%GRADE not reported 0 · 0%Very low 0 · 0%Low 14 · 58.3%Moderate 5 · 20.8%High 0 · 0%

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Aqueous tear production · people with dry eyea

Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) showed no clear difference in change in Schirmer test (aqueous tear production, measured in mm/5… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.68
7 studies · 1730 participants
Moderate

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Tear film stability · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 1640 participants
Low

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Change in tear osmolarity (measured in mOsmol/L, with reductions in osmolarity indicating clinical improvement) at 1‐month (with actual · people with dry eyea

Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) showed no clear difference in change in tear osmolarity (measured in mOsmol/L, with reductions in… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 54 participants
Low

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Adverse event: gastrointestinal disorders at 1‐month (with actual · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 719 participants
Low