Findings

What do systematic reviews say?

21 questions · 21 findings · 2 reviews · Musculoskeletal

No studies found 8 · 38.1%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 9 · 42.9%High 4 · 19%

Total adverse events · participants with tophi in gout

Pegloticase every two weeks (biweekly) showed no clear difference in total adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for tophi in gout 2021 · Cochrane Headline outcomes only
RR 0.99 [0.91, 1.07]
1 study · 128 participants
Moderate