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Evidence found and GRADE certainty

22 questions · 22 findings · 2 reviews · Headline outcomes only

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No studies found 9 · 40.9%GRADE not reported 0 · 0%Very low 3 · 13.6%Low 3 · 13.6%Moderate 6 · 27.3%High 1 · 4.5%

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

EEG sedative‐induced artefact · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) leads to lower EEG sedative‐induced artefact compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (high certainty).

1 finding from 1 review

Chloral hydrate oral (100 mg/kg or 75 mg/kg) vs midazolam

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (100 mg/kg or 75 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with midazolam (intranasal 0.2 mg/kg or oral 0.5 mg/kg) (low certainty).

1 finding from 1 review