Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

59 questions · 61 findings · 3 reviews · Pregnancy and Childbirth

No studies found 14 · 23%GRADE not reported 6 · 9.8%Very low 18 · 29.5%Low 18 · 29.5%Moderate 5 · 8.2%High 0 · 0%

Intravenous iron vs oral iron

All gastrointestinal symptoms Reported by the women · women with postpartum iron deficiency anaemia

It is very uncertain whether intravenous iron changes all gastrointestinal symptoms Reported by the women compared with oral iron (very low certainty).

1 finding from 1 review

Intravenous iron vs oral iron

Anaphylaxis or evidence of hypersensitivity Clinical assessment · women with postpartum iron deficiency anaemia

Intravenous iron showed no clear difference in anaphylaxis or evidence of hypersensitivity Clinical assessment compared with oral iron (low certainty).

1 finding from 1 review

Any intermittent iron regimen (with or without other vitamins and minerals) vs daily regimen (with same vitamins and minerals)‐maternal outcomes

Maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and at least 1 additional laboratory indicators at 37 weeks' gestation or more) · Women receiving supplements in pregnancy

It is very uncertain whether any intermittent iron regimen (with or without other vitamins and… changes maternal iron‐deficiency anaemia at term (Hb less than 110 g/L and… compared with daily regimen (with same vitamins and minerals)‐maternal outcomes (very low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Low birthweight · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in low birthweight (less than 2500 g) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Preterm birth · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in preterm birth (less than 37 weeks of gestation) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (moderate certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Neonatal death (death within the first 28 days of life) · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in neonatal death (within 28 days after delivery) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Any congenital anomalies · pregnant women

(Infant outcomes) Any supplements containing iron showed no clear difference in congenital anomalies (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Maternal severe anaemia at any time during 2nd or 3rd trimester (Hb less than 70 g/L) · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes maternal severe anaemia at any time during second and third… compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Infection during pregnancy (including urinary tract infections and others) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron showed no clear difference in infection during pregnancy (including urinary tract infections) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Maternal anaemia at term (Hb less than 110 g/L at 37 weeks' gestation or more) (ALL) · pregnant women

(Maternal outcomes) Any supplements containing iron may leads to lower maternal anaemia at term (Hb less than 110 g/L at 37 weeks'… compared with same supplements without iron or no treatment/placebo (no iron or… (low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Maternal death · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes maternal death (death while pregnant or within 42 days of… compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

1 finding from 1 review

Any supplements containing iron vs same supplements without iron or no treatment/placebo (no iron or placebo)

Side effects (any reported throughout the intervention period) (ALL) · pregnant women

It is very uncertain whether (Maternal outcomes) Any supplements containing iron changes side effects (any reported throughout the intervention period) (ALL) compared with same supplements without iron or no treatment/placebo (no iron or… (very low certainty).

1 finding from 1 review

Any supplements containing iron and folic acid vs same supplements without iron nor folic acid (no iron nor folic acid or placebo)

Low birthweight · pregnant women

(Infant outcomes) Any supplements containing iron and folic acid showed no clear difference in low birthweight (less than 2500 g) (ALL) compared with same supplements without iron nor folic acid (no iron nor folic acid… (low certainty).

1 finding from 1 review