What do systematic reviews say?

Oral iron vs placebo or no treatment

The review found no eligible studies for this question.

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral iron vs placebo or no treatment

Oral iron showed no clear difference in clinical malaria compared with placebo or no treatment (high certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.93 [0.87, 1]
  14 studies · 7168 participants
  High

Oral iron vs placebo or no treatment

Oral iron showed no clear difference in clinical malaria Subgrouped by population anaemia (trial level) compared with placebo or no treatment (moderate certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.92 [0.84, 1]
  14 studies · 7168 participants
  Moderate

Oral iron vs placebo or no treatment

Oral iron leads to lower severe malaria Defined as clinical malaria with high‐grade… compared with placebo or no treatment (high certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.9 [0.81, 0.98]
  6 studies · 3421 participants
  High

Oral iron vs placebo or no treatment

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  no estimate extracted
  18 studies · 7576 participants
  Low

Oral iron vs placebo or no treatment

It is very uncertain whether oral iron changes hospitalization plus clinic visits compared with placebo or no treatment (very low certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 0.99 [0.95, 1.04]
  6 studies · 12578 participants
  Very low

Oral iron vs inactive control

It is very uncertain whether oral iron changes mortality compared with inactive control (very low certainty).

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  RR 1.05 [0.68, 1.61]
  4 studies · 659 participants
  Very low

Oral iron vs inactive control

It is very uncertain whether oral iron changes proportion requiring blood transfusion compared with inactive control (very low certainty).

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  RR 0.74 [0.55, 0.99]
  3 studies · 546 participants
  Very low

Oral iron vs inactive control

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 300 participants
  Very low

Oral iron vs inactive control

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 402 participants
  Very low

Oral iron vs inactive control

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 276 participants
  Very low

Oral iron vs inactive control

It is very uncertain whether oral iron changes serious adverse events compared with inactive control (very low certainty).

• Iron therapy in anaemic adults without chronic kidney disease 2014 · Cochrane Headline outcomes only
  RR 0.96 [0.76, 1.22]
  5 studies · 731 participants
  Very low

IV or oral iron alone vs no treatment

IV or oral iron alone showed no clear difference in red blood cell transfusions (Subnet based on 69 studies including… compared with no treatment (low certainty).

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  RR 0.74 [0.43, 1.28]
  Studies not reported
  Low

IV or oral iron alone vs no treatment

IV or oral iron alone showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  RR 1.5 [0.63, 3.56]
  Studies not reported
  Low

IV or oral iron alone vs no treatment

The review found no eligible studies for this question.

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IV or oral iron alone vs no treatment

The review found no eligible studies for this question.

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IV or oral iron alone vs no treatment

The review found no eligible studies for this question.

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

IV or oral iron alone vs no treatment

IV or oral iron alone showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  RR 2.95 [0.71, 12.34]
  Studies not reported
  Low

IV or oral iron alone vs no treatment

The review found no eligible studies for this question.

• Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Oral iron with antimalarial prophylaxis vs placebo or no treatment

Oral iron with antimalarial prophylaxis showed no clear difference in all‐cause mortality compared with placebo or no treatment (low certainty).

• Oral iron supplements for children in malaria‐endemic areas 2016 · Cochrane Headline outcomes only
  RR 1.05 [0.52, 2.11]
  728 participants
  Low