Findings

What do systematic reviews say?

29 questions · 31 findings · 1 reviews · Heart

No studies found 2 · 6.5%GRADE not reported 0 · 0%Very low 6 · 19.4%Low 6 · 19.4%Moderate 9 · 29%High 8 · 25.8%

Serum triglyceride, ALA ‐ fasting TG, mmol/L · adults with or without existing CVD

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1776 participants
Moderate

Cardiovascular events · adults with or without existing CVD

High showed no clear difference in cardiovascular events compared with low long‐chain omega‐3 fats (high certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.96 [0.92, 1.01]
43 studies · 140482 participants
High

Serum high density lipoprotein – ALA – HDL, mmol/L · adults with or without existing CVD

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1776 participants
Moderate

Coronary heart disease mortality – CHD deaths · adults with or without existing CVD

High showed no clear difference in coronary heart disease mortality – CHD deaths compared with low long‐chain omega‐3 fats (low certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.9 [0.81, 1]
24 studies · 127378 participants
Low

CHD events · adults with or without existing CVD

High may leads to lower coronary heart disease events – CHD events compared with low long‐chain omega‐3 fats (low certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.91 [0.85, 0.97]
32 studies · 134116 participants
Low

Stroke · adults with or without existing CVD

High showed no clear difference in stroke compared with low long‐chain omega‐3 fats (moderate certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 1.02 [0.94, 1.12]
31 studies · 138888 participants
Moderate

Arrhythmias · adults with or without existing CVD

High showed no clear difference in arrhythmias compared with low long‐chain omega‐3 fats (low certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 0.99 [0.92, 1.06]
30 studies · 77990 participants
Low

Harms: bleeding · adults with or without existing CVD

It is very uncertain whether high changes harms: bleeding compared with low long‐chain omega‐3 fats (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 1.12 [0.91, 1.37]
11 studies · 80147 participants
Very low

Harms: pulmonary embolus or DVT · adults with or without existing CVD

It is very uncertain whether high changes harms: pulmonary embolus or DVT compared with low long‐chain omega‐3 fats (very low certainty).

1 finding from 1 review

Omega‐3 fatty acids for the primary and secondary prevention of cardiovascular disease 2020 · Cochrane Headline outcomes only
RR 1.15 [0.44, 2.98]
5 studies · 3546 participants
Very low