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What do systematic reviews say?

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Evidence found and GRADE certainty

328 questions · 332 findings · 35 reviews

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No studies found 83 · 25%GRADE not reported 11 · 3.3%Very low 75 · 22.6%Low 105 · 31.6%Moderate 45 · 13.6%High 13 · 3.9%

NSAIDs vs placebo

Inflammation: participants with no swelling at 72 hours (canakinumab 150 mg) Assessed by the investigator as no swelling, mild/palpable, moderate/visible, severe/bulging beyond the joint margins · acute gout

NSAIDs showed no clear difference in inflammation: swelling compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Function: ≥ 50% improvement in pain with movement at 24 hours · acute gout

NSAIDs showed no clear difference in function: ≥ 50% improvement in pain with movement at 24 hours compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Proportion of participants experiencing global improvement % of dichotomized Likert scale · Patients with acute low‐back pain

NSAIDs may leads to higher proportion of participants experiencing global improvement Various… compared with placebo (low certainty).

1 finding from 1 review

NSAIDs vs placebo

Proportion of participants experiencing adverse events · Patients with acute low‐back pain

It is very uncertain whether NSAIDs changes proportion of participants experiencing adverse events compared with placebo (very low certainty).

1 finding from 1 review