Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

36 questions · 36 findings · 3 reviews

No studies found 16 · 44.4%GRADE not reported 0 · 0%Very low 4 · 11.1%Low 9 · 25%Moderate 7 · 19.4%High 0 · 0%

RhDNase vs placebo

Lung function: FEV1 mL (percentage change from baseline) · people with bronchiectasis

RhDNase showed no clear difference in lung function % change FEV1 compared with placebo (low certainty).

1 finding from 1 review

Erdosteine vs no treatment

Frequency and duration of exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Erdosteine vs no treatment

Hospitalisations for infective exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Erdosteine vs no treatment

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Erdosteine vs no treatment

Symptoms mucus volume production · people with bronchiectasis

Erdosteine showed no clear difference in symptoms mucus volume production compared with no treatment (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Hospital admissions · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Erdosteine vs no treatment

FEV1 · people with bronchiectasis

Erdosteine may leads to higher lung function change in FEV1 (L) at day 15 compared with no treatment (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Adverse events · people with bronchiectasis

Bromhexine showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Health‐related quality of life · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Bromhexine vs placebo

Symptoms difficulty in expectoration · people with bronchiectasis

Bromhexine showed no clear difference in symptoms difficulty in expectoration compared with placebo (low certainty).

1 finding from 1 review

Bromhexine vs placebo

Deaths · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Bromhexine vs placebo

Lung function (FEV₁) · people with bronchiectasis

Bromhexine showed no clear difference in lung function FEV1 compared with placebo (low certainty).

1 finding from 1 review

RhDNase vs placebo

Frequency and duration of exacerbations · people with bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

RhDNase vs placebo

Hospitalisations for infective exacerbations · people with bronchiectasis

RhDNase showed no clear difference in hospitalisations for infective exacerbations compared with placebo (low certainty).

1 finding from 1 review