Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

128 questions · 130 findings · 12 reviews · Epilepsy

No studies found 18 · 13.8%GRADE not reported 5 · 3.8%Very low 3 · 2.3%Low 47 · 36.2%Moderate 37 · 28.5%High 20 · 15.4%

Clonazepam vs carbamazepine

Proportion of participants with treatment‐emergent adverse events (TEAEs) ‐ Leading to discontinuation during the treatment period № of participants: 36 (1 RCT) · people with newly diagnosed epilepsy

It is very uncertain whether clonazepam changes proportion of participants with treatment‐emergent adverse events… compared with carbamazepine (very low certainty).

1 finding from 1 review

Sulthiame vs levetiracetam

Adverse effects (cardiac) · participants with epilepsy (BECTS)

Sulthiame showed no clear difference in adverse effects (cardiac) compared with levetiracetam (low certainty).

1 finding from 1 review