Patient‐reported symptoms of eczema · children and adults, most with moderate to severe eczema
Twice daily or more showed no clear difference in patient‐reported symptoms of eczema: PGA (number with cleared or… compared with once daily topical corticosteroid (low certainty).
1 finding from 1 review
Local adverse events: skin thinning; end of treatment (2‐5 weeks) · children and adults, most with moderate to severe eczema
1 finding from 1 review
Systemic adverse events: abnormal cortisol; end of treatment (1‐6 weeks) · children and adults, most with moderate to severe eczema
1 finding from 1 review
Intervention not reported
Placebo · patients with moderate to severe eczema
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Tezepelumab (1 RCT; 56 participants) · patients with moderate to severe eczema
The intervention showed no clear difference in tezepelumab (1 RCT; 56 participants) (low certainty).
1 finding from 1 review
Intervention not reported
Lebrikizumab (1 RCT; 156 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes lebrikizumab (1 RCT; 156 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
PF‐04965842 (1 RCT; 211 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes PF‐04965842 (1 RCT; 211 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
Tralokinumab (1 RCT; 153 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes tralokinumab (1 RCT; 153 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
Apremilast (1 RCT; 121 participants) · patients with moderate to severe eczema
The intervention showed no clear difference in apremilast (1 RCT; 121 participants) (low certainty).
1 finding from 1 review
Intervention not reported
Baricitinib (1 RCT; 75 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes baricitinib (1 RCT; 75 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
Placebo · patients with moderate to severe eczema
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Total studies: 6 RCTsTotal participants: 1720 · patients with moderate to severe eczema
1 finding from 1 review
Intervention not reported
Dupilumab (3 RCTs; 1082 participants) · patients with moderate to severe eczema
The intervention showed no clear difference in dupilumab (3 RCTs; 1082 participants) (low certainty).
1 finding from 1 review
Intervention not reported
Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
Placebo · patients with moderate to severe eczema
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Fezakinumab (1 RCT; 40 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes fezakinumab (1 RCT; 40 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
QGE031 (1 RCT; 10 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes QGE031 (1 RCT; 10 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
Cyclosporin A (2 RCTs; 49 participants) · patients with moderate to severe eczema
It is very uncertain whether the intervention changes cyclosporin A (2 RCTs; 49 participants) (very low certainty).
1 finding from 1 review
Intervention not reported
Placebo · patients with moderate to severe eczema
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Total studies: 13 RCTsTotal participants: 1658 · patients with moderate to severe eczema
1 finding from 1 review