Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

516 questions · 545 findings · 51 reviews · Gynaecology and Fertility

No studies found 129 · 23.7%GRADE not reported 5 · 0.9%Very low 196 · 36%Low 162 · 29.7%Moderate 51 · 9.4%High 2 · 0.4%

Metabolomics vs non metabolomics

Clinical pregnancy (Presence of a fetal heart on ultrasound scan at seven weeks of gestation) · Women undergoing IVF/ICSI cycles

Metabolomics showed no clear difference in clinical pregnancy (Presence of a fetal heart on ultrasound scan at… compared with non metabolomics (low certainty).

1 finding from 1 review

Metformin vs megestrol

Hysterectomy rate · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes hysterectomy rate compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Abnormal uterine bleeding · endometrial hyperplasia

It is very uncertain whether summary of findings table ‐ Metformin changes abnormal uterine bleeding compared with megestrol (very low certainty).

1 finding from 1 review

Metformin vs megestrol

Adverse effects during treatment ‐ not reported · endometrial hyperplasia

The review found no eligible studies for this question.

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Fibroids · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in fibroids compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Abnormal Vaginal Bleeding or Spotting · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance probably leads to higher abnormal vaginal bleeding or spotting compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Breast cancer recurrence · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in breast cancer recurrence compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review

The LNG‐IUS with endometrial surveillance vs endometrial surveillance alone

Breast Cancer‐related Death · endometrial protection in women with breast cancer on adjuvant tamoxifen

The LNG‐IUS with endometrial surveillance showed no clear difference in breast cancer‐related death compared with endometrial surveillance alone (moderate certainty).

1 finding from 1 review