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Evidence found and GRADE certainty

139 questions · 139 findings · 8 reviews · Headline outcomes only

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No studies found 39 · 28.1%GRADE not reported 8 · 5.8%Very low 23 · 16.5%Low 31 · 22.3%Moderate 25 · 18%High 13 · 9.4%

Lithium vs QUETIAPINE

Efficacy: response (continuous) Change in YMRS (ITT‐LOCF) from baseline to end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 359 participants
    Low

Lithium vs QUETIAPINE

Remission · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) Decrease in YMRS ≤ 12 by end of… compared with quetiapine (low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.64 [0.26, 1.57]
    2 studies · 359 participants
    Low

Lithium vs placebo

Remission · acute mania

Lithium leads to higher efficacy: remission (categorical) YMRS < 12 at end of study compared with placebo (high certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 2.16 [1.73, 2.69]
    5 studies · 1597 participants
    High

Lithium vs QUETIAPINE

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with quetiapine (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.38 [0.83, 2.28]
    2 studies · 359 participants
    Very low

Lithium vs QUETIAPINE

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs OLANZAPINE

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

Lithium probably leads to lower efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score… compared with olanzapine (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.44 [0.2, 0.94]
    2 studies · 180 participants
    Moderate

Lithium vs OLANZAPINE

Efficacy: response (continuous) CGI severity score at end of study · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 210 participants
    Low

Lithium vs OLANZAPINE

Remission · acute mania

Lithium showed no clear difference in efficacy: remission (categorical) YMRS ≤ 12 at end of study compared with olanzapine (low certainty).

1 finding from 1 review

Lithium vs OLANZAPINE

Acceptability: total withdrawals · acute mania

Lithium may leads to higher acceptability: total withdrawals compared with olanzapine (low certainty).

1 finding from 1 review

Lithium vs OLANZAPINE

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs chlorpromazine

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs chlorpromazine

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    2 studies · 284 participants
    Very low

Lithium vs chlorpromazine

Remission · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs placebo

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with placebo (moderate certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.76 [0.46, 1.25]
    7 studies · 1353 participants
    Moderate

Lithium vs chlorpromazine

Acceptability: total withdrawals · acute mania

Lithium showed no clear difference in acceptability: total withdrawals compared with chlorpromazine (low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 1.75 [0.92, 3.31]
    2 studies · 262 participants
    Low

Lithium vs chlorpromazine

Adverse events · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs haloperidol

Efficacy: response (categorical) MSRS/YMRS ≥ 50% decrease in score by end of study · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs haloperidol

Efficacy: response (continuous) change in BPRS (total) from baseline to end of study ‐all data · acute mania
1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    3 studies · 80 participants
    Very low

Lithium vs haloperidol

Remission · acute mania

The review found no eligible studies for this question.

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    no estimate extracted
    Studies not reported
    No studies found

Lithium vs haloperidol

Acceptability: total withdrawals · acute mania

It is very uncertain whether lithium changes acceptability: total withdrawals compared with haloperidol (very low certainty).

1 finding from 1 review
  • Lithium for acute mania 2019 · Cochrane Headline outcomes only
    OR 0.29 [0.03, 3.12]
    1 study · 30 participants
    Very low