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What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 156 findings · 14 reviews · Headline outcomes only

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No studies found 45 · 28.8%GRADE not reported 3 · 1.9%Very low 53 · 34%Low 31 · 19.9%Moderate 16 · 10.3%High 8 · 5.1%

Lidocaine vs tocainide

Cardiac mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes cardiac mortality compared with tocainide (very low certainty).

1 finding from 1 review

Lidocaine vs tocainide

Adverse events (AEs) (1 or more events) · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): any adverse event compared with tocainide (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

All‐cause mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes all‐cause mortality compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Cardiac mortality · patients with myocardial infarction

It is very uncertain whether lidocaine changes cardiac mortality compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Ventricular fibrillation · patients with myocardial infarction

It is very uncertain whether lidocaine changes ventricular fibrillation compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Adverse events (AEs; adverse drug reaction): atrioventricular block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): atrioventricular block compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs mexiletine

Adverse events (AEs; adverse drug reaction): composite neurological adverse event (confusion, vertigo, nystagmus, vomiting and diplopia) · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): composite neurological… compared with mexiletine (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Ventricular fibrillation · patients with myocardial infarction

It is very uncertain whether lidocaine changes ventricular fibrillation compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): heart failure · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): heart failure compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Adverse events (AEs; adverse drug reaction): bilateral bundle branch block · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): bilateral bundle branch… compared with propafenone (very low certainty).

1 finding from 1 review

Lidocaine vs propafenone

Neuropsychiatric adverse event · patients with myocardial infarction

It is very uncertain whether lidocaine changes adverse events (AEs; adverse drug reaction): neuropsychiatric… compared with propafenone (very low certainty).

1 finding from 1 review