What do systematic reviews say?

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clomiphene citrate or letrozole with or without gonadotropins (with… may leads to higher cancellation rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

• Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian… 2017 · Cochrane Headline outcomes only
  RR 1.46 [1.18, 1.81]
  10 studies · 1601 participants
  Low

IUI in a stimulated cycle vs TI or expectant management

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 4.48 [2, 10.01]
  1 study · 201 participants
  Moderate

IUI in a stimulated cycle vs TI or expectant management

IUI in a stimulated cycle probably leads to higher pregnancy rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

• Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
  OR 4.68 [2.22, 9.86]
  1 study · 201 participants
  Moderate

LOD vs medical interventions

• Ovarian surgery for symptom relief in women with polycystic ovary syndrome 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Progesterone vs placebo/no treatment

The review found no eligible studies for this question.

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in ongoing pregnancy rate compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.73 [0.37, 1.42]
  1 study · 253 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.67 [0.3, 1.5]
  2 studies · 123 participants
  Low

Progesterone vs placebo/no treatment

Progesterone may leads to higher clinical pregnancy rate compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 1.4 [1.03, 1.9]
  4 studies · 733 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in multiple pregnancy rate compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 1.44 [0.24, 8.49]
  1 study · 290 participants
  Low

Progesterone vs placebo/no treatment

The review found no eligible studies for this question.

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in live birth rate/ongoing pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.97 [0.58, 1.64]
  2 studies · 485 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.53 [0.25, 1.14]
  2 studies · 119 participants
  Low

Progesterone vs placebo/no treatment

Progesterone may leads to higher clinical pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 1.44 [1.04, 1.98]
  6 studies · 1073 participants
  Low

Progesterone vs placebo/no treatment

Progesterone showed no clear difference in multiple pregnancy compared with placebo/no treatment (low certainty).

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  RR 0.58 [0.1, 3.55]
  2 studies · 586 participants
  Low

Progesterone vs placebo/no treatment

The review found no eligible studies for this question.

• Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found