Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

39 questions · 48 findings · 5 reviews · Infectious Diseases

No studies found 2 · 4.2%GRADE not reported 1 · 2.1%Very low 8 · 16.7%Low 18 · 37.5%Moderate 13 · 27.1%High 6 · 12.5%

Intervention not reported

Improvement of clinical status: all initial symptoms resolved (asymptomatic) at day 14 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in improvement of clinical status: all initial symptoms resolved… (low certainty).

1 finding from 1 review

Intervention not reported

Improvement of clinical status: time to symptom resolution · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

QoL (physical component) at up to 28 days, measured on the PROMIS Global‐10 scale and normalized to values from 16.2, low QoL, to 67.2, maximum QoL · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in qoL (physical component) at up to 28 days, measured on the PROMIS… (high certainty).

1 finding from 1 review

Intervention not reported

QoL (mental component) at up to 28 days, measured on the PROMIS Global‐10 scale and normalized to values from 21.2, low QoL, to 67.6, maximum QoL · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in qoL (mental component) at up to 28 days, measured on the PROMIS… (high certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in serious adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Any adverse events during the trial period · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in any adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at day 7 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in viral clearance at day 7 (low certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: participants with new need for invasive mechanical ventilation or death at day 28 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes worsening of clinical status: participants with new need for… (very low certainty).

1 finding from 1 review

Intervention not reported

Improvement of clinical status: participants discharged alive at day 28 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in improvement of clinical status: participants discharged alive at day… (low certainty).

1 finding from 1 review

Intervention not reported

QoL at longest · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Serious adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

It is very uncertain whether the intervention changes serious adverse events during the trial period (very low certainty).

1 finding from 1 review

Intervention not reported

Any adverse events during the trial period · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in any adverse events during the trial period (low certainty).

1 finding from 1 review

Intervention not reported

Viral clearance at day 7 · people with moderate to severe disease (WHO scale 4–9); all trials contributing results to the summary of findings table investigated…

The intervention showed no clear difference in viral clearance at day 7 (low certainty).

1 finding from 1 review

Intervention not reported

All‐cause mortality at day 28 · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in all‐cause mortality at day 28 (moderate certainty).

1 finding from 1 review

Intervention not reported

Worsening of clinical status: admission to hospital or death within 28 days · all trials contributing results to the summary of findings table included people with mild disease (WHO scale 1 to 3)§

The intervention showed no clear difference in worsening of clinical status: admission to hospital or death within… (low certainty).

1 finding from 1 review