What do systematic reviews say?

Intravenous midazolam vs intravenous lorazepam

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure cessation compared with intravenous lorazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.91, 1.04]
  1 study · 80 participants
  Moderate

Intravenous midazolam vs intravenous lorazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  Moderate

Intravenous midazolam vs intravenous lorazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  High

Intravenous midazolam vs intravenous lorazepam

Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to terminate the seizure: additional dose… compared with intravenous lorazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 3 [0.13, 71.51]
  1 study · 80 participants
  Moderate

Intravenous midazolam vs intravenous lorazepam

Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous lorazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 1 [0.15, 6.76]
  1 study · 80 participants
  Moderate

Intravenous midazolam vs intravenous lorazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Buccal midazolam vs rectal diazepam

Summary of findings ‐ Buccal midazolam may leads to lower additional drugs required to stop the seizure: intravenous lorazepam… compared with rectal diazepam (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.58 [0.42, 0.79]
  1 study · 177 participants
  Low

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

Summary of findings ‐ Buccal midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (high certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.91 [0.8, 1.03]
  1 study · 120 participants
  High

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 120 participants
  Moderate

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 120 participants
  High

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Buccal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

Summary of findings ‐ Intranasal midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.98 [0.91, 1.06]
  2 studies · 122 participants
  Moderate

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  Moderate

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 122 participants
  High

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

The review found no eligible studies for this question.

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings ‐ Intranasal midazolam vs intravenous diazepam

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 52 participants
  High

Summary of findings ‐ Intramuscular midazolam vs intravenous diazepam

Summary of findings ‐ Intramuscular midazolam showed no clear difference in seizure cessation compared with intravenous diazepam (low certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.97 [0.87, 1.09]
  2 studies · 105 participants
  Low