What do systematic reviews say?

Infiltration injection local anaesthetic vs no treatment or placebo

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  No study reported parental satisfaction
  0 studies
  No studies found

Infiltration injection local anaesthetic vs no treatment or placebo

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on patient or child satisfaction
  0 studies
  No studies found

Infiltration injection local anaesthetic vs no treatment or placebo

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  2 studies · 174 participants
  Very low

Infiltration injection local anaesthetic vs no treatment or placebo

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes

  Postoperatively, typically up to discharge
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  6 studies · 542 participants
  Very low

Infiltration injection local anaesthetic vs no treatment or placebo

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on postoperative anxiety
  0 studies
  No studies found

Infiltration injection local anaesthetic vs no treatment or placebo

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  2 studies · 148 participants
  Very low

Intraligamental injection local anaesthetic vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Anand 2005 used the Venham Picture Scale but, owing to the split-mouth design, postoperative anxiety could not be compared between the LA and no-treatment sides
  1 study
  GRADE not reported

Intraligamental injection local anaesthetic vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  Anand 2005: no signs of postoperative soft tissue trauma, 21 children reported numbness on the LA (experimental) side; Sammons 2007: no adverse events reported
  2 studies
  GRADE not reported

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on this outcome
  0 studies
  No studies found

Intraligamental injection local anaesthetic vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes

  On regaining consciousness, up to 1 hour (1 study to 48 hours)
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  2 studies · 115 participants
  Very low

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  None of the studies reported on this outcome
  0 studies
  No studies found

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  No study reported parental satisfaction
  0 studies
  No studies found

Intraligamental injection local anaesthetic vs no treatment

The review found no eligible studies for this question.

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes
  The studies did not report on patient or child satisfaction
  0 studies
  No studies found

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

Salivary Lactobacilli counts were unchanged in two studies but significantly increased in one study one month after BoNT (ungraded; no effect estimate reported).

• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Before vs after BoNT injection (2018 study: significant Lactobacilli increase at 1 month; Wu 2011 and 2017 study no change) · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
  No statistically significant changes in Lactobacilli CFU counts were reported by Wu et al. or by Tiigimae-Saar 2017. However, the 2018 study found that Lactobacilli CFU counts were significantly increased one month…
  3 studies
  GRADE not reported

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

No included study reported salivary osmolality; this pre-planned outcome remains unassessed (no studies).

• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
  no estimate extracted
  0 studies
  No studies found

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

BoNT injections were not associated with significant changes in salivary S. mutans counts across three studies (ungraded; no effect estimate reported).

• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Before vs after BoNT injection · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
  The RCT by Wu et al. reported no statistically significant changes in S. mutans CFU counts (p-values only). The studies of Tiigimae-Saar did not find statistically significant differences in S. mutans CFU counts either.
  3 studies
  GRADE not reported

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

BoNT injections were not associated with significant changes in oral/salivary pH across three studies (ungraded; no effect estimate reported).

• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Before vs after BoNT injection · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
  Wu et al. did not observe significant differences in participants' oral pH before and after BoNT-A injections between the active and control groups. There were also no statistically significant differences regarding…
  3 studies
  GRADE not reported

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

In one RCT, BoNT-B 2500 U was not associated with a statistically significant increase in new caries versus placebo (RR 2.4, 95% CI 0.48 to 11.80; not significant).

• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care · BoNT-B 2500 U vs placebo (Isaacson RCT)
  RR 2.4 [0.48, 11.80]
  1 study
  GRADE not reported
• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care · BoNT-B 3500 U vs placebo (Isaacson RCT)
  RR 1.4 [0.24, 8.12]
  1 study
  GRADE not reported

Intraglandular botulinum neurotoxin (BoNT) injection vs No BoNT (placebo or pre-treatment baseline)

Salivary buffering capacity did not decrease after BoNT; one of two quasi-experimental studies reported a significant increase (ungraded; no effect estimate reported).

• Oral health effects of botulinum toxin treatment for drooling: a systematic review. 2020 All outcomes

  Before vs after BoNT injection (2018 study: significant buffering increase at 1 month; 2017 study no change) · Neurological-disease populations with drooling (e.g., cerebral palsy, Parkinson disease, adults with sialorrhea); specialist clinical care
  The quasi-experimental studies of Tiigimae-Saar found different results concerning the changes in buffering capacity. For the analysis carried out in 2017, no statistically significant change was observed. By contrast,…
  2 studies
  GRADE not reported

Infiltration injection LA and intraligamental injection LA (3-arm) vs no treatment

• Intraoperative local anaesthesia for reduction of postoperative pain following general anaesthesia for dental… 2014 · Cochrane All outcomes

  Up to 30 minutes postoperatively; parent-reported to first night
  Because of substantial clinical and methodological heterogeneity in the studies, we were unable to determine an estimate of effect
  1 study · 54 participants
  Very low