Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 2 reviews · Musculoskeletal

No studies found 2 · 6.1%GRADE not reported 3 · 9.1%Very low 0 · 0%Low 7 · 21.2%Moderate 10 · 30.3%High 11 · 33.3%

Intervention not reported

Withdrawals due to adverse events · participants with rheumatoid arthritis and with partial response to MTX

The intervention showed no clear difference in withdrawals due to adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with partial response to MTX

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Outcome: ACR50 ‐ American College of Rheumatology Improvement Criteria · participants with rheumatoid arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Remission Achievement of disease activity score < 2.6 · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention leads to higher remission Achievement of disease activity score < 2.6 (high certainty).

1 finding from 1 review

Intervention not reported

Reduction in disability score Health Assessment Questionnaire. Scale from: 0 to 3 · participants with rheumatoid arthritis and with a partial response to DMARDs
1 finding from 1 review

Intervention not reported

Radiographic progression Total Sharp Score Scale from: 0 to 448 · participants with rheumatoid arthritis and with a partial response to DMARDs
1 finding from 1 review

Intervention not reported

Withdrawals due to adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in withdrawals due to adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious adverse events (moderate certainty).

1 finding from 1 review

Intervention not reported

Serious infections · participants with rheumatoid arthritis and with a partial response to DMARDs

The intervention showed no clear difference in serious infections (high certainty).

1 finding from 1 review

Intervention not reported

ACR50 American College of Rheumatology improvement criteria · participants with rheumatoid arthritis and with partial response to MTX

The intervention probably leads to higher ACR50 American College of Rheumatology improvement criteria (moderate certainty).

1 finding from 1 review

Intervention not reported

Remission Disease activity score < 2.6 · participants with rheumatoid arthritis and with partial response to MTX
1 finding from 1 review