Droperidol vs OLANZAPINE
Economic: direct costs · acute psychosis
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Findings
What do systematic reviews say?
45 questions · 45 findings · 3 reviews
No studies found 2 · 4.4%GRADE not reported 11 · 24.4%Very low 2 · 4.4%Low 10 · 22.2%Moderate 11 · 24.4%High 9 · 20%
Droperidol vs placebo
Adverse effects ‐ cardiovascular ‐ arrhythmia · acute psychosis
Droperidol showed no clear difference in adverse effects ‐ cardiovascular ‐ arrhythmia compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.34 [0.01, 8.31]1 study · 227 participantsModerate
Droperidol vs placebo
Adverse effects ‐ respiratory ‐ airway obstruction · acute psychosis
Droperidol showed no clear difference in adverse effects ‐ respiratory ‐ airway obstruction compared with placebo (low certainty).
1 finding from 1 review
- RR 0.62 [0.15, 2.52]1 study · 227 participantsLow
Droperidol vs placebo
Service use: person able to be discharged home · acute psychosis
Droperidol showed no clear difference in service use: person able to be discharged home compared with placebo (high certainty).
1 finding from 1 review
- RR 1.16 [0.9, 1.48]1 study · 227 participantsHigh
Droperidol vs placebo
Mental state ‐ improvement · acute psychosis
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Droperidol vs placebo
Economic: direct costs · acute psychosis
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Droperidol vs haloperidol
Tranquillisation or asleep · acute psychosis
Droperidol showed no clear difference in tranquillisation or asleep: tranquillised/sleep ‐ by around 30 minutes compared with haloperidol (high certainty).
1 finding from 1 review
- RR 1.01 [0.93, 1.09]1 study · 228 participantsHigh
Droperidol vs haloperidol
Global state: use of additional medication ‐ by 60 minutes after initial adequate sedation until ED discharge (various psychotropic drugs) · acute psychosis
Droperidol leads to lower global state: use of additional medication ‐ by 60 minutes after… compared with haloperidol (high certainty).
1 finding from 1 review
- RR 0.37 [0.16, 0.9]2 studies · 255 participantsHigh
Intervention not reported
Droperidol (41 RCTs; 6156 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted41 studies · 6156 participantsModerate
Intervention not reported
Droperidol (21 RCTs; 3739 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted21 studies · 3739 participantsLow
Intervention not reported
Droperidol (22 RCTs; 3270 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted22 studies · 3270 participantsLow
Intervention not reported
Droperidol (0 RCTs; 0 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
Intervention not reported
Droperidol (0 RCTs; 0 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted0 studies · 0 participantsGRADE not reported
Intervention not reported
Droperidol (7 RCTs; 659 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted7 studies · 659 participantsVery low
Intervention not reported
Droperidol (5 RCTs; 682 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted5 studies · 682 participantsVery low
Intervention not reported
Droperidol (3 RCTs; 303 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted3 studies · 303 participantsLow
Intervention not reported
Droperidol (2 RCTs; 304 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 304 participantsLow
Intervention not reported
Droperidol (2 RCTs; 1622 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted2 studies · 1622 participantsLow
Intervention not reported
Droperidol (22 RCTs; 3679 participants) · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…
1 finding from 1 review
- Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta‐analysis 2020 · Cochrane Headline outcomes onlyno estimate extracted22 studies · 3679 participantsModerate
HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL
Tranquillisation or asleep ‐ not asleep up to 2 hours · psychosis‐induced aggression or agitation
HALOPERIDOL showed no clear difference in tranquillisation or asleep ‐ not asleep up to 2 hours compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).
1 finding from 1 review
- Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes onlyRR 1.07 [0.44, 2.6]1 study · 228 participantsModerate